Step 1: After having downloaded and installed Pandora: First Contact and before running the game, please open your free avast! 2014 program and click on "Settings":

Step 2: After having clicked on "Active Protection" please select "File System Shield":

Step 3: On the next panel please select "Exclusion" and click on "browse".

Step 4: On the next panel browse in your local disk and select the folder where Pandora: First Contact is installed.
Steam version default location: Steam\SteamApps\common\Pandora
Slitherine/Matrix version default location: Program Files (x86)\Slitherine\Pandora

Step 5: Click "OK" on both panels to save the new settings and exit.

Now that the exclusion area was created you can start Pandora: First Contact