I have hit them with multiple shots, front, side, rear etc. Have hit them with Artillery barrages. Have hit them with fighter planes. Have hit them with carpet bombings. Except for a rare random kill or two, they basically just keep going. In Cobra scenario they game about 5 Tigers that just do whatever they want killing unit after unit while being seemingly invincible. Aggressive attack by allies and you get slaughtered. Stay back in defensive positions and wait for them to attack and you get slaughtered.
So, how do you kill a tiger?

Just a comment I have also been surprised how many tanks the game gives the Germans they even seem to have more tanks than the allies. So now they seem to have the expected superior tanks but also more of them.